Scientists from the Montreal Neurological Institute in Canada and the University of Oklahoma in the US have found the brain circuit behind misophonia's 'Rage Response', a reaction to everyday sounds. The study, published in Human Brain Mapping, found that the anterior insular cortex and salience network of the brain are closely tied to misophoni. It also revealed that there is not a clear delineation between people with misophonian and those without. The researchers used functional magnetic resonance imaging (fMRI) scans of resting brains for 162 adults in an existing database, which did not include specific information on misophon. They found that misophonic symptom severity was associated with synced with areas of the salience system responsible for auditory processing and motor and movement planning. The findings could aid in understanding the condition's neural mechanisms and potentially help in understanding how it's triggered.