Christina Applegate details ‘excruciating agony’ of MS, from burning skin to numbness to diapers
By Mckenzie Beard
Published on March 3, 2026.
Christina Applegate, an Emmy Award-winning actress and actress, has written a new memoir about her life-changing diagnosis of multiple sclerosis (MS) in which she details the excruciating agony she faces. She was diagnosed with the chronic autoimmune disease in June 2021 at the age of 49 and shared the news with fans two months later. The chronic illness, which attacks myelin, causes inflammation and scrambling signals between the brain and body. Nearly 1 million Americans are believed to be living with the disease, which can morph over time and can cause symptoms such as burning skin, numbness, and frequent hospital visits. Applegate details her exhaustion and physical pain. She also reveals that she has to regularly rush to the emergency room in agony and regularly wears adult diapers due to the disease.
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