Chile researchers have found that mice given sucralose or stevia may have multigenerational effects, potentially altering metabolism in future generations even without direct consumption. The findings suggest that these sweeteners triggered changes in gut bacteria and gene activity, which were then passed down across generations. The study does not prove that the same thing happens in humans. However, it adds to a growing body of research looking into whether non-nutritive sweeteners really have no effect on the body as many people believe. The lead author, Francisca Concha Celume, urges further research into the long-term biological effects of these additives. Approximately 140 million Americans consume non-Nutritive sugar substitutes regularly.