Negleria fowleri, a "brain-eating amoeba," or "Brain-eating Amoebas," are nearly always fatal and are often fatal. The Centers for Disease Control and Prevention (CDC) has confirmed 157 confirmed human cases of N. fowlerI in the US between 1962 and 2022, and only four survivors survived. However, new drugs may be available to combat this disease, with the most recently approved new medication for primary amebic meningoencephalitis (PAM), the disease caused by N. Fowleri, may also be on the horizon as well. The disease, which destroys brain tissue, infects people by accident when water is forced up the nose, causing water to drive it through a lacy bone called the cribriform plate to the olfactory nerve. N.fowleri thrives in warm fresh water around 80 degrees Fahrenheit (26.6 degrees Celsius) or warmer, thrives best in cooler temperatures. Immunocompromised people are at higher risk due to higher rates of infection. There are currently only six and six cases between the age of 12 each year in the U.S. each year.