The Cleveland Guardians defeated the Seattle Mariners 6-4 in the teams' season opener at T-Mobile Park in Seattle. Chase DeLauter homered twice and Jose Ramirez broke a tie with a two-run double in the seventh inning. Dominic Canzone and Brendan Donovan each contributed to the score. The victory was secured by Connor Brogdon and Cade Smith, who were making their Mariners debuts. The game was the first regular-season game for DeLauther and his last for the Mariners.