Christina Applegate's A-list friends and former co-stars, Ed O'Neill and Katey Sagal, are reportedly "anguished" over her health after her recent hospitalization. The celebrities have reportedly reached out to Applegate, expressing their concern over her situation. They have made sure that nothing is left unsaid regarding their relationship. Other celebrities who reportedly offered support include Linda Cardellini, Will Ferrell and Jean Smart. Applegate was diagnosed with MS in 2021 and has been open about her health issues.