Teddi Mellencamp was hospitalized after suffering from Stevens-Johnson syndrome, a rare disorder of the skin and mucous membranes caused by a new medication she was on. The symptoms included a painful rash and painful sores all over her body. Despite her diagnosis of stage 2 melanoma in 2022 and undergoing numerous surgeries, she has since begun immunotherapy and is still considered stage four. Her ex-husband, Edwin Arroyave, said the immunotherapy is hard on her mental health and that she is just starting to move her body again. Despite rumors of illness, Mellencamps has expressed gratitude for her progress and gratitude for the support she has received.