Creatine, a supplement to enhance both strength and recovery, and brain health, has been found to be beneficial for both these areas due to its ability to help cells generate energy. However, a recent review article found that creatine’s role in the muscle-brain axis can be found in four key pathways through which it may influence the muscle–brain axis. These include BDNF, Cathepsin B, IGF-1, Irisin, and Lactate, which acts as a signaling molecule that supports neurogenesis and neuron survival. The study also identified six key myokines with the clearest link to brain health. Creatine may enhance the myokine response to exercise and potentially shift the timing of myokina release. It is also found that by improving ATP availability, muscles contract more effectively, it could allow muscles to contract more easily. The research also indicates that a higher 10-gram daily dose of creatine is more effective.