Kratom, a plant that has been hailed as a potential treatment for opioid use disorder, has seen a 6,500% increase in poison center calls nationwide over the past decade and a half. The National Institute on Drug Abuse (NIDA) has reported that kratom's unregulated proliferation in the US has led to severe side effects and increased calls to poison centers. The FDA has not approved kratom for medical use and it is not currently scheduled under the US Controlled Substances Act. A new report from the Society for the Study of Addiction and the Medical College of Wisconsin suggests that states with no regulations consistently had worse outcomes than states that banned kratom use. The study also found that krastrastrastanism can cause seizures, irregular heart rhythms, liver damage and breathing problems, and that if combined with other drugs, kratom’s tendency to interfere with metabolic pathways can make other drugs more dangerous.