The best upset picks for every region in the 2026 Men's NCAA Tournament Bracket are based on the recent trend of upsets in the tournament. These picks include 14th-seeded North Dakota State over No. 3 Michigan State, 14th nationally in three-point percentage, and No. 13 Troy over No 4 Nebraska. No 12 Akron over No 5 Texas Tech, and 12 High Point over Wisconsin, could potentially advance to the Sweet 16. The rankings are subjective, with an emphasis on mid- and low-major programs. The last time an underdog has played in the NCAA tournament, Purdue lost to Fairleigh Dickinson.