Researchers have found that the use of psychedelic drugs could break the cycle of repetitive thought patterns, which can lead to negative fixations. This could be because psychedelics make neurons fire in a more random, excitable way, forcing a person to abandon their fixed narratives. Some studies have shown that psilocybin physically alters brain structures after a single use. The theory of Relaxed Beliefs Under Psychedelics (REBUS) and Revised Beliefs After Psychedelicics (RABAS), originally proposed by psychedelic expert Robin Carhart-Harris, PhD, who founded the Centre for Psychedelicism Research at Imperial College London. ReBUS is connected to a brain that operates in unpredictable ways, causing predictable thought patterns. The main effect of these psychedelics is that they disrupt those predictable patterns and lead to anxiety and depression.