The global incidence of dengue has increased tenfold over the past two decades, rising from 500,000 reported cases in 2000 to 5.2 million in 2019. In the WHO South-East Asia Region, outbreaks are becoming more frequent, unpredictable, and geographically widespread. To combat this, effective surveillance must go beyond case detection and use of genomic data as a tool for identifying emerging variants, understanding transmission dynamics, and informing vaccine and outbreak response strategies. A regional workshop organised by WHO SEARO and CSIR-Institute of Genomics and Integrative Biology (IGIB), hosted by the Institute, led by laboratory experts and public health professionals from Timor-Leste, Nepal and Bhutan to strengthen capacity in genomic surveillance. The workshop emphasized three interconnected objectives: strengthening technical capacity for dengued genomic sequencing, standardizing approaches to bioinformatics analysis across countries, and translating genomic data into actionable public health intelligence.