Protests across Pakistan have resulted in at least 20 deaths and dozens of injuries across the country following a US-Israel strike on Tehran that killed Iran's supreme leader, Ayatollah Ali Khamenei. The deaths included 10 people in Karachi, at least eight in Skardu, and two in Islamabad. Demonstrations were largely led by members of Pakistan's Shia Muslim community, who account for over 20 percent of the population. The country, which is predominantly Sunni Muslim, is predominantly Shia, with Shia accounting for more than 20 percent. The Pakistani government has condemned the joint US-Israeli military attack on Iran and criticised Iran's subsequent attacks on Gulf nations. The US Embassy in Islamabad warned of ongoing demonstrations and advised citizens to avoid large crowds.