Researchers have discovered that a gene that produces an exceptional amount of hyaluronic acid, or HMM-HA, may protect naked mole rats from aging and potentially make them resistant to cancer. This gene was transferred to mice, who lived longer and avoided health issues such as inflammation and cancer. The researchers modified mice to express the hyaluranic acid synthase 2 gene (nmrHas2), which increased their lifespans and healthspan. The study also found that the transferred naked mole rat gene made mice more resistant to disease and reduced deaths from cancer. HMM/HA is not synthesized in naked mole Rats until after birth due to its slow proliferation of cells. Researchers used a CAG promoter to mimic the way that naked moleRat tissues accumulate HOM-HA.