The San Francisco Giants lost 7-0 to the New York Yankees on Opening Night, marking Tony Vitello's first regular-season game as a professional. The game was marked by a lacklustre performance from Logan Webb, who allowed seven runs (six earned) over five innings with seven strikeouts to one walk. This marked only the third time Webb allowed at least seven runs in his career that he did so. The Giants' sloppy defense also stood out, with shortstop Willy Adames nearly throwing a ball into right field and a fielder trying to throw out José Caballero.