Former Republican Nebraska Sen. Ben Sasse has been diagnosed with Stage 4 pancreatic cancer, which affects 64,000 Americans annually and has a five-year relative survival rate of approximately 3.2%. Despite learning of his diagnosis just weeks before Christmas, Sasse remains optimistic and determined to live. He addressed his situation with hope and clarity, framing his announcement as a time to make peace with his life's turn. Sasse, a Reformed Lutheran–Calvinist, takes daraxonrasib, a drug by Revolution Medicines orally, rather than an injection. He has been living in Florida but attends a clinical trial in Houston twice weekly.