Scientists have discovered a potential weakness in antibiotic-resistant bacteria, including Acinetobacter baumannii, which often causes infection in hospital settings. The researchers identified a unique sugar molecule, Pse, which is found only on the outsides of bacterial cells and can make the bacteria vulnerable to the immune system. If proven, this could offer a new approach to tackling a wide array of superbugs, including those such as A. baumannaii, Helicobacter pylori, and Campylobacter jejuni. Researchers developed monoclonal antibodies that bind specific sugars across multiple bacteria to create a highly specific biological targeting system. They believe these antibodies could be used to develop vaccines that offer broad protection against Gram-negative bacteria long-term. However, the main limitation is that the sugars, pseudaminic acid, are not expressed on all bacteria.