Resident Evil Requiem, the final chapter of the Umbrella Corporation series, is known for its references to previous games in the series. The game's Easter Egg includes an obscure Resident Evil Outbreak reference and a reference to Lady Dimitrescu's signature blood wine. The first time Grace Ashcroft uses a lockpick to open a drawer in the game, players will receive the “Like mother, like Daughter” achievement on PS5 and Xbox, a reference from the 2003 Resident Evil outbreak. This achievement is an Easter Egg to the PS2-era game and protagonist, Alyssa Ashcroft, who is known in the Outbreak storyline for being good at picking locks. Another Easter Egg involves a change in the backstory of Leon and Robert's encounter in RE9, which has a significant impact on Leon’ character. The Secret Capcom Locker in the RPD contains references to several classic games, including the original PlayStation 1 Resident Evil, Mega Man 8, and Street Fighter Alpha 2 game discs.