Ben Starr, known for his portrayal of Final Fantasy 16 protagonist Clive Rosfield, played the character Prometheus in Hades 2, which is considered one of the hardest bosses in the game. In an interview with the Academy of Interactive Arts & Sciences, Starr admitted to feeling frustrated while playing the game and "hating" himself. He also mentioned that he had to send a picture of Prometheus defeated when he finally defeated him to one of his friends. The guide on how to beat Prometheus in Hiera, which explains which weapons and Boons are recommended for the game, also includes several tips specifically geared towards the boss fight.