Buffy the Vampire Slayer Cast Reacts to Nicholas Brendon’s Death
By Lindsay Weinberg
Published on March 21, 2026.
Nicholas Brendon, the actor who played Xander Harris on Buffy the Vampire Slayer from 1997 to 2003, passed away at age 54 from natural causes. Brendon had been battling health issues, including a congenital heart defect and cauda equina syndrome, which is caused by nerve damage at the base of the spinal cord. He starred alongside Sarah Michelle Gellar, Anthony Head, James Marsters, and the late Michelle Trachtenberg. His family remembered him for his passion in painting and art, and his love for the Buffy universe. Despite his struggles, Brendon remained optimistic about his future in the show.
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